Free shipping on all orders over $ 500

Calcitonin (salmon)

Cat. No. M10801
Calcitonin (salmon) Structure
Synonym:

Salmon calcitonin

Size Price Availability Quantity
1mg USD 120  USD120 In stock
5mg USD 240  USD240 In stock
10mg USD 345  USD345 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Calcitonin salmon is a calcium-regulating hormone that is a dual agonist of amylin and calcitonin receptors that stimulate bone production and inhibit bone resorption.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 3431.85
Formula C145H240N44O48S2
CAS Number 47931-85-1
Purity >98%
Solubility Water ≥ 60 mg/mL
Storage at -20°C
References

[1] Akash Srinivasan, et al. J Musculoskelet Neuronal Interact. Calcitonin: A useful old friend

[2] P M Sexton, et al. Curr Med Chem. Calcitonin

[3] A Itabashi. Nihon Rinsho. [Calcitonin]

[4] J Y Reginster. Rev Med Liege. [Calcitonin]

[5] J T Potts Jr, et al. Curr Top Exp Endocrinol. Calcitonin

Related CGRP Receptor Products
Ubrogepant

Ubrogepant (MK-1602) is a novel oral calcitonin gene-associated peptide receptor (CGRP) antagonist with the potential to be used in acute migraine studies.

Vazegepant hydrochloride

Vazegepant (BHV-3500) hydrochloride is a highly affinity CGRP receptor antagonist (hCGRP Ki= 0.023 nM).

Rimegepant

Rimegepant, also known as BMS-927711, is a potent, selective, competitive, and orally active calcitonin gene-related peptide (CGRP) antagonist with a Ki value of 0.027 nM.

Olcegepant (BIBN-4096)

Olcegepant (BIBN-4096) is a potent and selective non-peptide antagonist of the calcitonin gene-related peptide (CGRP) receptor with IC50 of 0.03 nM and Ki of 14.4 pM for human CGRP.

BAR501

BAR501 is a potent and selective agonist of GPBAR1 with an EC50 of 1 μM.

  Catalog
Abmole Inhibitor Catalog




Keywords: Calcitonin (salmon), Salmon calcitonin supplier, CGRP Receptor, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.