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Calcitonin (salmon)

Cat. No. M10801
Calcitonin (salmon) Structure
Synonym:

Salmon calcitonin

Size Price Availability Quantity
1mg USD 120  USD120 In stock
5mg USD 240  USD240 In stock
10mg USD 345  USD345 In stock
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Quality Control & Documentation
Biological Activity

Calcitonin salmon is a calcium-regulating hormone that is a dual agonist of amylin and calcitonin receptors that stimulate bone production and inhibit bone resorption.

Chemical Information
Molecular Weight 3431.85
Formula C145H240N44O48S2
CAS Number 47931-85-1
Solubility (25°C) Water ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Akash Srinivasan, et al. J Musculoskelet Neuronal Interact. Calcitonin: A useful old friend

[2] P M Sexton, et al. Curr Med Chem. Calcitonin

[3] A Itabashi. Nihon Rinsho. [Calcitonin]

[4] J Y Reginster. Rev Med Liege. [Calcitonin]

[5] J T Potts Jr, et al. Curr Top Exp Endocrinol. Calcitonin

Related CGRP Receptor Products
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Adrenomedullin (16-31), human is amino acid residues 16-31 fragment of human adrenomedullin (hADM).

α-CGRP(human)

α-CGRP(human) is a regulatory neuropeptide of 37 amino acids.

Adrenomedullin (AM) (22-52), human

Adrenomedullin (AM) (22-52), human is an adrenomedullin receptor antagonist, and also antagonizes the calcitonin generelated peptide (CGRP) receptor in the hindlimb vascular bed of the cat.

Calcitonin Gene Related Peptide (CGRP) II, rat

Calcitonin Gene Related Peptide (CGRP) II, rat, a CGRP receptor activator, is a potent and long-lasting vasodilator.

Adrenomedullin (11-50), rat

Adrenomedullin (11-50), rat is the C-terminal fragment (11-50) of rat adrenomedullin.

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