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Caffeic acid

Cat. No. M3979
Caffeic acid Structure
Size Price Availability Quantity
100mg USD 60  USD75 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Caffeic acid inhibited 5-lipoxygenase in a non-competitive manner. Caffeic acid and its methyl ester did not inhibit prostaglandin synthase activity at all, at least up to 5 X 10(-4) M, but rather stimulate at higher doses.Caffeic acid has been shown to inhibit arachidonic acid metabolism in platelets at high doses.It has been observed to stimulate prostaglandin synthesis at high doses. Caffeic acid is an inhibitor of GST, ODC, Tyk and Xanthine Oxidase.Caffeic acid inhibits the synthesis of leukotrienes that are involved in immunoregulation, inflammation and allergy.Caffeic acid inhibits Cu2+-induced LDL oxidation.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 180.16
Formula C9H8O4
CAS Number 331-39-5
Purity >98%
Solubility DMSO 40mg/mL
Ethanol 25mg/mL
Storage at -20°C
References

[1] Yamanaka N, et al. FEBS Lett. Prooxidant activity of caffeic acid, dietary non-flavonoid phenolic acid, on Cu2+-induced low density lipoprotein oxidation.

[2] Ploemen JH, et al. Food Chem Toxicol. In vitro and in vivo reversible and irreversible inhibition of rat glutathione S-transferase isoenzymes by caffeic acid and its 2-S-glutathionyl conjugate.

[3] Koshihara Y, et al. Biochim Biophys Acta. Caffeic acid is a selective inhibitor for leukotriene biosynthesis.

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