Caffeic acid inhibited 5-lipoxygenase in a non-competitive manner. Caffeic acid and its methyl ester did not inhibit prostaglandin synthase activity at all, at least up to 5 X 10(-4) M, but rather stimulate at higher doses.Caffeic acid has been shown to inhibit arachidonic acid metabolism in platelets at high doses.It has been observed to stimulate prostaglandin synthesis at high doses. Caffeic acid is an inhibitor of GST, ODC, Tyk and Xanthine Oxidase.Caffeic acid inhibits the synthesis of leukotrienes that are involved in immunoregulation, inflammation and allergy.Caffeic acid inhibits Cu2+-induced LDL oxidation.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
Prooxidant activity of caffeic acid, dietary non-flavonoid phenolic acid, on Cu2+-induced low density lipoprotein oxidation.
Yamanaka N, et al. FEBS Lett. 1997 Mar 24;405(2):186-90. PMID: 9089288.
In vitro and in vivo reversible and irreversible inhibition of rat glutathione S-transferase isoenzymes by caffeic acid and its 2-S-glutathionyl conjugate.
Ploemen JH, et al. Food Chem Toxicol. 1993 Jul;31(7):475-82. PMID: 8340025.
Caffeic acid is a selective inhibitor for leukotriene biosynthesis.
Koshihara Y, et al. Biochim Biophys Acta. 1984 Jan 17;792(1):92-7. PMID: 6318834.
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