Free shipping on all orders over $ 500
Cadazolid is a new antibiotic in development for the treatment of Clostridium difficile-associated diarrhea. Cadazolid is active against all (including linezolid- and moxifloxacin-resistant) Clostridium difficile strains (MIC90 0.125, range 0.03-0.25 mg/L). The cadazolid geometric mean MIC is 152-fold, 16-fold, 9-fold and 7-fold lower than those of moxifloxacin, linezolid, metronidazole and vancomycin, respectively. Both cadazolid dosing regimens rapidly reduce Clostridium difficile viable counts and cytotoxin with no evidence of recurrence.
| Cell Experiment | |
|---|---|
| Cell lines | C. difficile |
| Preparation method | Experiments to assess the effects of cadazolid and comparator antibiotics on C. difficile toxin formation were done by determination of toxin A and B concentrations in stationary-phase cultures of toxigenic C. difficile |
| Concentrations | 0.3% (vol/vol) DMSO |
| Incubation time | 24 h |
| Animal Experiment | |
|---|---|
| Animal models | Hamster model of CDAD |
| Formulation | 0.5% [wt/wt] methylcellulose containing 0.05% [wt/vol] Tween 80 |
| Dosages | 10 mg/kg |
| Administration | gavage |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Molecular Weight | 505.55 |
| Formula | C29H29F2N3O8 |
| CAS Number | 1025097-10-2 |
| Purity | >98% |
| Solubility | DMSO ≥ 90 mg/mL |
| Storage | at -20°C |
| Related Antibiotic Products |
|---|
| Olanexidine
Olanexidine is an antiseptic/disinfectant compound with potent bactericidal activity against Gram-negative and Gram-positive bacteria. |
| DIMBOA
DIMBOA is a powerful antibiotic present in maize, wheat, and related grasses, possess growth inhibitory properties against many strains of studied bacteria and fungi, such as Staphylococcus aureus, Escherichia coli as well as against Saccharomyces cerevisiae. |
| Ciprofloxacin hydrochloride
Ciprofloxacin hydrochloride is a β-diketone antibiotic with a broad spectrum antibacterial activity. |
| Tosufloxacin tosylate hydrate
Tosufloxacin tosylate hydrate is a fluoroquinolone antibacterial agent used to treat susceptible infections. |
| Tylosin
Tylosin is a macrolide antibiotic obtained from cultures of Streptomyces fradiae. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.
