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Cadazolid

Cat. No. M6091
Cadazolid Structure
Synonym:

ACT-179811

Size Price Availability Quantity
5mg USD 110 In stock
50mg USD 650 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Notwithstanding the limitations of the study sample size, there was no evidence that increasing the cadazolid dosage above 250 mg BID improved efficacy. In the present study, the most frequent PCR ribotype and restriction endonuclease analysis (REA) group were 027 and BI, respectively. Fecal cadazolid concentrations for all dosages of cadazolid were several thousandfold higher than the C. difficile MIC, and the baseline and postbaseline cadazolid MICs were low (≤0.5 mg/liter), including those for the epidemic strains. In addition, minimal impacts on the intestinal microflora were observed at all dosages of cadazolid.

Protocol
Cell Experiment
Cell lines C. difficile
Preparation method Experiments to assess the effects of cadazolid and comparator antibiotics on C. difficile toxin formation were done by determination of toxin A and B concentrations in stationary-phase cultures of toxigenic C. difficile
Concentrations 0.3% (vol/vol) DMSO
Incubation time 24 h
Animal Experiment
Animal models Hamster model of CDAD
Formulation 0.5% [wt/wt] methylcellulose containing 0.05% [wt/vol] Tween 80
Dosages 10 mg/kg
Administration gavage
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 505.55
Formula C29H29F2N3O8
CAS Number 1025097-10-2
Purity >98%
Solubility 10 mM in DMSO
Storage at -20°C
References

Multicenter, Double-Blind, Randomized, Phase 2 Study Evaluating the Novel Antibiotic Cadazolid in Patients with Clostridium difficile Infection.
Louie T, et al. Antimicrob Agents Chemother. 2015 Oct;59(10):6266-73. PMID: 26248357.

In vitro and in vivo antibacterial evaluation of cadazolid, a new antibiotic for treatment of Clostridium difficile infections.
Locher HH, et al. Antimicrob Agents Chemother. 2014;58(2):892-900. PMID: 24277020.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Cadazolid, ACT-179811 supplier, inhibitors

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