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C75 trans

Cat. No. M9508
C75 trans Structure


Size Price Availability Quantity
5mg USD 125  USD125 In stock
10mg USD 205  USD205 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

C75 trans is an enantiomer of C75, which is a synthetic fatty-acid synthase (FASN) inhibitor. trans-C75 ((±)-C75) inhibits PC3 cell growht with an IC50 of 35 μM at 24 h. trans-C75 ((±)-C75)(10-50 μM) also reduces the growth of LNCaP spheroids in a concentration-dependent manner with an IC50 of 50 μM. 

In vivo, intraperitoneal administration of C75 at 30 mg/kg body weight inhibits food intake of mice by ≥95% within 2 h after i.p. injection. C75 treatment of rodent adipocytes and hepatocytes and human breast cancer cells increases fatty acid oxidation and ATP levels by increasing CPT-1 activity, even in the presence of elevated concentrations of malonyl-CoA.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 254.32
Formula C14H22O4
CAS Number 191282-48-1
Purity >99%
Solubility DMSO ≥ 25 mg/mL
Storage at -20°C

[1] James S Jensen, et al. Preformulation stability of trans-resveratrol and trans-resveratrol glucoside (Piceid)

[2] Melissa E Gondert, et al. Catalytic core structure of the trans-acting HDV ribozyme is subtly influenced by sequence variation outside the core

[3] P C Bevilacqua, et al. Linkage between proton binding and folding in RNA: implications for RNA catalysis

[4] Rebecca A Tinsley, et al. Magnesium dependence of the amplified conformational switch in the trans-acting hepatitis delta virus ribozyme

[5] J Ofengand, et al. Pseudouridines and pseudouridine synthases of the ribosome

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Abmole Inhibitor Catalog

Keywords: C75 trans, (±)-C75 supplier, FAS, inhibitors

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