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C-Type Natriuretic Peptide (CNP) (1-22), human

Cat. No. M10358
C-Type Natriuretic Peptide (CNP) (1-22), human Structure
Synonym:

CNP-22, human

Size Price Availability Quantity
1mg USD 150  USD150 In stock
5mg USD 600  USD600 In stock
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Quality Control & Documentation
Biological Activity

C-Type Natriuretic Peptide (CNP) (1-22), human is the 1-22 fragment of C-Type Natriuretic Peptide. C-Type Natriuretic Peptide (CNP) has been shown to be present in the central nervous system of mammals and to participate in the regulation of the homeostasis of the fluid, electrolytic balance and blood pressure, learning and memory.

Chemical Information
Molecular Weight 2197.6
Formula C93H157N27O28S3
CAS Number 127869-51-6
Solubility (25°C) Water 10 mg/mL
Storage -20°C, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] A M Mazarati, et al. Life Sci. ANP(1-28), BNP(1-32) and CNP(1-22) increase the severity of picrotoxin-kindled seizure syndrome in rats

[2] W K Samson, et al. Brain Res. CNP-22 stimulates, rather than inhibits, water drinking in the rat: evidence for a unique biological action of the C-type natriuretic peptides

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Keywords: C-Type Natriuretic Peptide (CNP) (1-22), human, CNP-22, human supplier, Angiotensin Receptor, inhibitors, activators


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