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Bupivacaine

Cat. No. M10074
Bupivacaine Structure
Synonym:

CAS# 38396-39-3

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500mg USD 50  USD50 In stock
1g USD 80  USD80 In stock
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Biological Activity

Bupivacaine is a NMDA receptor inhibitor. Bupivacaine can block sodium, L-calcium, and potassium channels. Bupivacaine potently blocks SCN5A channels with the IC50 of 69.5 μM. Bupivacaine can be used for the research of chronic pain. Bupivacaine acts by binding to the intracellular portion of voltage-gated sodium channels and blocking sodium influx into nerve cells.

Chemical Information
Molecular Weight 288.43
Formula C18H28N2O
CAS Number 2180-92-9
Solubility (25°C) methanol 10 mg/mL
chloroform 10 mg/mL
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Alexandra R Carlson, et al. Vet Surg. Sterility and concentration of liposomal bupivacaine single-use vial when used in a multiple-dose manner

[2] Andrea Casati, et al. Best Pract Res Clin Anaesthesiol. Bupivacaine, levobupivacaine and ropivacaine: are they clinically different?

[3] E Kalso, et al. Ann Chir Gynaecol. Bupivacaine and intravenous regional anaesthesia--a matter of controversy

[4] P A Moore. Oral Surg Oral Med Oral Pathol. Bupivacaine: a long-lasting local anesthetic for dentistry

[5] D Suresh. Ann R Coll Surg Engl. Bupivacaine squirting

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