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BTdCPU

Cat. No. M9513
BTdCPU Structure
Size Price Availability Quantity
5mg USD 335 In stock
10mg USD 525 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

BTdCPU is an potent activator of HRI, it promotes eIF2α phosphorylation and induced apoptosis in resistant cell. Combination therapy with rapamycin and BTdCPU, demonstrated additive effects on apoptosis in dex-resistant cells.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 339.20
Formula C13H8Cl2N4OS
CAS Number 1257423-87-2
Purity >99%
Solubility DMSO ≥ 100 mg/mL
Storage at -20°C
References

The eIF2-alpha kinase HRI is a novel therapeutic target in multiple myeloma.
Burwick N, et al. Leuk Res. 2017 Apr;55:23-32. PMID: 28119225.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: BTdCPU supplier, Phosphatase, inhibitors

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