BTdCPU is an potent activator of HRI, it promotes eIF2α phosphorylation and induced apoptosis in resistant cell. Combination therapy with rapamycin and BTdCPU, demonstrated additive effects on apoptosis in dex-resistant cells.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||DMSO ≥ 100 mg/mL|
The eIF2-alpha kinase HRI is a novel therapeutic target in multiple myeloma.
Burwick N, et al. Leuk Res. 2017 Apr;55:23-32. PMID: 28119225.
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