BSJ-03-123 is a potent and novel CDK6-selective small-molecule degrader.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||DMSO 10 mM|
Homolog-Selective Degradation as a Strategy to Probe the Function of CDK6 in AML.
Brand M, et al. Cell Chem Biol. 2019 Feb 21;26(2):300-306.e9. PMID: 30595531.
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