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BSJ-03-123

Cat. No. M9239
BSJ-03-123 Structure
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

BSJ-03-123 is a potent and novel CDK6-selective small-molecule degrader.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 937.01
Formula C47H56N10O11
CAS Number
Purity >98%
Solubility DMSO 10 mM
Storage at -20°C
References

Homolog-Selective Degradation as a Strategy to Probe the Function of CDK6 in AML.
Brand M, et al. Cell Chem Biol. 2019 Feb 21;26(2):300-306.e9. PMID: 30595531.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: BSJ-03-123 supplier, CDK, inhibitors

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