Free shipping on all orders over $ 500

Bruceine A

Cat. No. M3963

Bruceine A Structure
Size Price Availability Quantity
5mg USD 360 In stock
10mg USD 520 In stock
Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Bruceine A inhibited the in vitro growth of Babesia gibsoni in canine erythrocytes at lower concentration compared with the standard antibabesial compound diminazene aceturate and killed the parasites within 24 hr at a concentration of 25 nM.Both bruceine A and D exhibited significant activity against D. intermedius with EC(50) values of 0.49 mg l(-1) and 0.57 mg l(-1), respectively, which were more effective than the positive control, mebendazole (EC(50) value=1.25 mg l(-1)). In addition, the 48-h median lethal concentration (LC(50)) for bruceine A and D against the host (Carassius auratus) was 10.6-fold and 9.7-fold higher than the EC(50) for D. intermedius.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 522.54
Formula C26H34O11
CAS Number 25514-31-2
Purity >99%
Solubility DMSO
Storage at -20°C
References

In vivo anthelmintic activity of bruceine A and bruceine D from Brucea javanica against Dactylogyrus intermedius (Monogenea) in goldfish (Carassius auratus).
Wang Y, et al. Vet Parasitol. 2011 Apr 19;177(1-2):127-33. PMID: 21196080.

NF-kappaB inhibitors from Brucea javanica exhibiting intracellular effects on reactive oxygen species.
Kim JA, et al. Anticancer Res. 2010 Sep;30(9):3295-300. PMID: 20944100.

Evaluation of efficacy of bruceine A, a natural quassinoid compound extracted from a medicinal plant, Brucea javanica, for canine babesiosis.
Nakao R, et al. J Vet Med Sci. 2009 Jan;71(1):33-41. PMID: 19194074.

Bruceine A.
Xue-Huan Feng, et al. Acta Crystallogr Sect E Struct Rep Online. 2010 Apr 1;66(Pt 4): o854–o855. PMID: 2983995.

Related NF-κB Products
Dimethyl Fumarate

Dimethyl fumarate(DMF) is a nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator; induces upregulation of antioxidant gene expression.

5-Aminosalicylic acid

5-Aminosalicylic acid is a specific inhibitor of TNFα-induced IKK activity, used to treat inflammatory bowel disease.

GSK583

GSK583 is a highly potent and selective inhibitor of RIP2 kinase with an IC50 of 5 nM.

SC75741

SC75741 is a potent NF-κB inhibitor with EC50 of 200 nM.

PDTC

PDTC is a selective NF-kB inhibitor.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Bruceine A supplier, NF-κB, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.