Bruceine A inhibited the in vitro growth of Babesia gibsoni in canine erythrocytes at lower concentration compared with the standard antibabesial compound diminazene aceturate and killed the parasites within 24 hr at a concentration of 25 nM.Both bruceine A and D exhibited significant activity against D. intermedius with EC(50) values of 0.49 mg l(-1) and 0.57 mg l(-1), respectively, which were more effective than the positive control, mebendazole (EC(50) value=1.25 mg l(-1)). In addition, the 48-h median lethal concentration (LC(50)) for bruceine A and D against the host (Carassius auratus) was 10.6-fold and 9.7-fold higher than the EC(50) for D. intermedius.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
In vivo anthelmintic activity of bruceine A and bruceine D from Brucea javanica against Dactylogyrus intermedius (Monogenea) in goldfish (Carassius auratus).
Wang Y, et al. Vet Parasitol. 2011 Apr 19;177(1-2):127-33. PMID: 21196080.
NF-kappaB inhibitors from Brucea javanica exhibiting intracellular effects on reactive oxygen species.
Kim JA, et al. Anticancer Res. 2010 Sep;30(9):3295-300. PMID: 20944100.
Evaluation of efficacy of bruceine A, a natural quassinoid compound extracted from a medicinal plant, Brucea javanica, for canine babesiosis.
Nakao R, et al. J Vet Med Sci. 2009 Jan;71(1):33-41. PMID: 19194074.
Xue-Huan Feng, et al. Acta Crystallogr Sect E Struct Rep Online. 2010 Apr 1;66(Pt 4): o854–o855. PMID: 2983995.
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