Bromocriptine, an ergoline derivative, is a dopamine agonist that is used in the treatment of pituitary tumors, Parkinson's disease (PD), hyperprolactinaemia, neuroleptic malignant syndrome, and type 2 diabetes.
Neural Regen Res. 2024 May;19(5):1142-1149.
Bromocriptine protects perilesional spinal cord neurons from lipotoxicity after spinal cord injury
Bromocriptine Mesylate purchased from AbMole
| Molecular Weight | 750.7 |
| Formula | C32H40BrN5O5.CH4O3S |
| CAS Number | 22260-51-1 |
| Solubility (25°C) | DMSO ≥ 50 mg/mL |
| Storage | -20°C, protect from light, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[3] Christy M Weiland, et al. Bromocriptine mesylate (Cycloset) for type 2 diabetes mellitus
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