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Bromhexine HCl

Cat. No. M5468
Bromhexine HCl Structure
Size Price Availability Quantity
100mg USD 72  USD80 In stock
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Biological Activity

Bromhexine HCl is a medication prescribed for coughs which works by dissolving hard phlegm.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 412.59
Formula C14H20Br2N2.HCl
CAS Number 611-75-6
Purity >98%
Solubility 6 mg/mL in DMSO
Storage at -20°C

Solubility and solution stability studies of different amino acid prodrugs of bromhexine.
Aggarwal AK, et al. Drug Dev Ind Pharm. 2012 Nov;38(11):1319-27. PMID: 22283553.

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