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Brinzolamide

Cat. No. M2469
Brinzolamide Structure
Synonym:

AL-4862

Size Price Availability Quantity
25mg USD 100  USD100 In stock
50mg USD 160  USD160 In stock
100mg USD 280  USD280 In stock
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Quality Control & Documentation
Biological Activity

Brinzolamide (Brinzolamide) is a potent and effective carbonic anhydrase-II inhibitor with an IC50 of 3.19 nM.In addition, Brinzolamide reduces intraocular aqueous humor production in the eye and may be used in studies related to glaucoma.

Chemical Information
Molecular Weight 383.51
Formula C12H21N3O5S3
CAS Number 138890-62-7
Solubility (25°C) DMSO 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jonathan W Young, et al. Brinzolamide-induced Follicular Conjunctivitis

[2] No authors listed. Brinzolamide

[3] Sarah L Greig, et al. Brinzolamide/brimonidine: a review of its use in patients with open-angle glaucoma or ocular hypertension

[4] Ingrida Januleviciene. Brinzolamide 1%/timolol 0.5%: safety and efficacy of a new fixed-combination IOP-lowering product for glaucoma

[5] Michele Iester. Brinzolamide

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  Catalog
Abmole Inhibitor Catalog




Keywords: Brinzolamide, AL-4862 supplier, Carbonic Anhydrase, inhibitors, activators


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