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Brevianamide F

Cat. No. M8922
Brevianamide F Structure
Synonym:

Cyclo(L-Pro-L-Trp)

Size Price Availability Quantity
10mg USD 180 In stock
50mg USD 550 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Brevianamide F belongs to a class of naturally occurring 2,5-diketopiperazines. Brevianamide F is the simplest member and the biosynthetic precursor of a large family of biologically active prenylated tryptophan-proline 2,5-diketopiperazines. It shown to have antifungal activity against T. rubrum, C. neoformans and C. albicans, better than amphotericin B.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 283.33
Formula C16H17N3O2
CAS Number 38136-70-8
Purity >98%
Solubility DMSO
Storage at -20°C
References

Beyond the Diketopiperazine Family with Alternatively Bridged Brevianamide F Analogues.
Wauters I, et al. J Org Chem. 2015 Aug 21;80(16):8046-54. PMID: 26193166.

Identification of a brevianamide F reverse prenyltransferase BrePT from Aspergillus versicolor with a broad substrate specificity towards tryptophan-containing cyclic dipeptides.
Yin S, et al. Appl Microbiol Biotechnol. 2013 Feb;97(4):1649-60. PMID: 22660767.

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Keywords: Brevianamide F, Cyclo(L-Pro-L-Trp) supplier, inhibitors

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