Brevianamide F belongs to a class of naturally occurring 2,5-diketopiperazines. Brevianamide F is the simplest member and the biosynthetic precursor of a large family of biologically active prenylated tryptophan-proline 2,5-diketopiperazines. It shown to have antifungal activity against T. rubrum, C. neoformans and C. albicans, better than amphotericin B.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
Beyond the Diketopiperazine Family with Alternatively Bridged Brevianamide F Analogues.
Wauters I, et al. J Org Chem. 2015 Aug 21;80(16):8046-54. PMID: 26193166.
Identification of a brevianamide F reverse prenyltransferase BrePT from Aspergillus versicolor with a broad substrate specificity towards tryptophan-containing cyclic dipeptides.
Yin S, et al. Appl Microbiol Biotechnol. 2013 Feb;97(4):1649-60. PMID: 22660767.
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