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BRD73954

Cat. No. M5200

BRD73954 Structure
Size Price Availability Quantity
5mg USD 95 In stock
10mg USD 160 In stock
50mg USD 480 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

BRD73954 does not only retained HDAC6 inhibitory activity (IC50 = 0.036 μM) but resulted in a 10-fold increase in potency for HDAC8 (IC50 = 0.12 μM) with a concomitant reduction in potency for HDAC2.

In vitro: While treatment BRD73954 with resulted in a robust increase in α-tubulin acetylation, no change in the acetylation state of H3 was observed, which is consistent with the ability of these compounds to inhibit HDAC6 but not HDACs 1, 2, or 3 in the biochemical assay in HeLa cells.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 284.31
Formula C16H16N2O3
CAS Number 1440209-96-0
Purity >99%
Solubility DMSO 30 mg/mL
Storage at -20°C
References

Discovery of the first histone deacetylase 6/8 dual inhibitors.
Olson DE, et al. J Med Chem. 2013 Jun 13;56(11):4816-20. PMID: 23672185.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: BRD73954 supplier, HDAC, inhibitors

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