Free shipping on all orders over $ 500

BRCA1-IN-2

Cat. No. M9864
BRCA1-IN-2 Structure
Synonym:

BRCA1-IN II

Size Price Availability
5mg USD 480  USD480 4-7 Days
10mg USD 800  USD800 4-7 Days
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

BRCA1-IN-2 is a cell-permeable protein-protein interaction (PPI) inhibitor for BRCA1, with IC50 of 0.31 μM and Kd of 0.3 μM. BRCA1-IN-2 has antitumor activities via the disruption of BRCA1 (BRCT)2/protein interactions.

Chemical Information
Molecular Weight 544.54
Formula C26H33N4O7P
CAS Number 1622262-55-8
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Zhenkun Na, et al. Methods Mol Biol. Protein-Protein Interaction Inhibitors of BRCA1 Discovered Using Small Molecule Microarrays

Related PARP Products
DSB-1522

DSB-1522 is a PARP1 inhibitor that can be used in tumor-related studies.

DM-5167

DM-5167 is a PARP1 inhibitor that can be used in studies related to triple negative breast cancer.

NMS-03305293

NMS-03305293 is a PARP inhibitor with high selectivity for PARP1 isoforms and low DNA capture effect, which specifically kills BRCA mutated tumor cells. In addition, NMS-03305293 can penetrate the blood-brain barrier and can be used in studies related to CNS tumors and brain metastatic tumors.

SNV1521

SNV1521 is a potential best-in-class (BIC), highly selective and CNS-permeable PARP1 inhibitor.

Basroparib

Basroparib is an orally active selective inhibitor of end-anchor polymerase (TNKS) and an inhibitor of ribose polymerase (PARP) with antitumor activity.

  Catalog
Abmole Inhibitor Catalog




Keywords: BRCA1-IN-2, BRCA1-IN II supplier, PARP, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.