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BRCA1-IN-2

Cat. No. M9864
BRCA1-IN-2 Structure
Synonym:

BRCA1-IN II

Size Price Availability
5mg USD 432  USD480 4-7 Days
10mg USD 720  USD800 4-7 Days
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

BRCA1-IN-2 is a cell-permeable protein-protein interaction (PPI) inhibitor for BRCA1, with IC50 of 0.31 μM and Kd of 0.3 μM. BRCA1-IN-2 has antitumor activities via the disruption of BRCA1 (BRCT)2/protein interactions.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 544.54
Formula C26H33N4O7P
CAS Number 1622262-55-8
Purity >98%
Solubility DMSO
Storage at -20°C
References

Protein-Protein Interaction Inhibitors of BRCA1 Discovered Using Small Molecule Microarrays
Zhenkun Na, et al. Methods Mol Biol. 2017;1518:139-156. PMID: 27873205.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: BRCA1-IN-2, BRCA1-IN II supplier, PARP, inhibitors

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