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Brassinolide

Cat. No. M9314
Brassinolide Structure
Synonym:

Brassin lactone

Size Price Availability Quantity
10mg USD 105  USD105 In stock
25mg USD 235  USD235 In stock
50mg USD 375  USD375 In stock
100mg USD 585  USD585 In stock
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Quality Control
  • Current batch:
  • Purity >90%
  • COA
  • MSDS
Biological Activity

Brassinolide is a naturally occurring plant hormone that promotes growth, increases yields for grain and fruit crops, and makes plants more resistant to drought and cold weather. Brassinolide could induce a time and concentration-dependent cytotoxicity in PC-3 cells. Treatment with brassinolide triggers a time-dependent decrease in the expression of anti-apoptotic protein Bcl-2 and marked accumulation in G2/M phase of cell cycle.

Product Citations
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 480.68
Formula C28H48O6
CAS Number 72962-43-7
Purity >90%
Solubility DMSO: ≥ 5 mg/mL
Storage at -20°C
References

[1] Wu YD, et al. Pharmazie. Brassinolide, a plant sterol from pollen of Brassica napus L., induces apoptosis in human prostate cancer PC-3 cells.

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