Brassinolide is a naturally occurring plant hormone that promotes growth, increases yields for grain and fruit crops, and makes plants more resistant to drought and cold weather. Brassinolide could induce a time and concentration-dependent cytotoxicity in PC-3 cells. Treatment with brassinolide triggers a time-dependent decrease in the expression of anti-apoptotic protein Bcl-2 and marked accumulation in G2/M phase of cell cycle.
J Exp Bot. 2021 Jun 22;72(13):4721-4743.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
|Solubility||DMSO: ≥ 5 mg/mL|
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D-(+)-Malic acid (D-Malic acid) is an active isomer of Malic acid and acted as a competitive inhibitor of L(-)malic acid transport.
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