Bohemine served as a kinase inhibitor in the activation of bovine oocytes. Inhibition of DNA synthesis in oocytes was shown to be reversible, because after removal from boheminesupplemented medium the activated oocytes started to synthesize DNA. An attempt at elucidating the molecular basis of bohemine activity was undertaken through employing proteomics technology.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||10 mM in DMSO|
Diverse effects of the cyclin-dependent kinase inhibitor bohemine: Concentration- and time-dependent suppression or stimulation of hybridoma culture
Franek F, et al. Cytotechnology. 2001 Jul;36(1-3): 117–123. PMID: 19003322.
In vivo metabolism of 2,6,9-trisubstituted purine-derived cyclin-dependent kinase inhibitor bohemine in mice: glucosidation as the principal metabolic route.
Chmela Z, et al. Drug Metab Dispos. 2001 Mar;29(3):326-34. PMID: 11181503.
Elamipretide, also known as MTP-131, is a cardiolipin peroxidase inhibitor and mitochondria-targeted peptide.
Hexacosanoic acid is a long-chain fatty acid related to various diseases such as adrenoleukodystrophy (ALD), adrenomyeloneuropathy (AMN) and atherosclerosis.
Corn oil, extracted from the germ of corn, can be used as a carrier for drug molecules and has anti-tumor activity.
Palosuran, also known as ACT-058362, is a Urotensin-II receptor antagonist with an IC50 of 3.6±0.2 nM.
Dithiothreitol (DTT) is the common name for a small-molecule redox reagent known as Cleland's reagent; as a reducing or "deprotecting" agent for thiolated DNA.
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