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Cat. No. M6160
Bohemine Structure
Size Price Availability Quantity
5mg USD 125 In stock
10mg USD 220 In stock
25mg USD 350 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Bohemine served as a kinase inhibitor in the activation of bovine oocytes. Inhibition of DNA synthesis in oocytes was shown to be reversible, because after removal from boheminesupplemented medium the activated oocytes started to synthesize DNA. An attempt at elucidating the molecular basis of bohemine activity was undertaken through employing proteomics technology.

Cell Experiment
Cell lines
Preparation method
Incubation time
Animal Experiment
Animal models
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 340.42
Formula C18H24N6O
CAS Number 189232-42-6
Purity >99%
Solubility 10 mM in DMSO
Storage at -20°C

Diverse effects of the cyclin-dependent kinase inhibitor bohemine: Concentration- and time-dependent suppression or stimulation of hybridoma culture
Franek F, et al. Cytotechnology. 2001 Jul;36(1-3): 117–123. PMID: 19003322.

In vivo metabolism of 2,6,9-trisubstituted purine-derived cyclin-dependent kinase inhibitor bohemine in mice: glucosidation as the principal metabolic route.
Chmela Z, et al. Drug Metab Dispos. 2001 Mar;29(3):326-34. PMID: 11181503.

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Abmole Inhibitor Catalog 2017

Keywords: Bohemine supplier, inhibitors

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