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BMVC-8C3O

Cat. No. M9527
BMVC-8C3O Structure
Size Price Availability Quantity
5mg USD 400 In stock
10mg USD 680 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

BMVC-8C3O is a DNA G-quadruplexe (G4) ligand which can induce topological conversion of non-parallel to parallel forms in human telomeric DNA G4s. BMVC-8C3O induces topological conversion of Tel23 from a hybrid-I G4 to a parallel G4 in K+solution.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 1042.61
Formula C42H53I3N4O3
CAS Number 1301708-12-2
Purity >99%
Solubility DMSO ≥ 50 mg/mL (may need ultrasonic)
Storage at -20°C
References

A Novel Transition Pathway of Ligand-Induced Topological Conversion From Hybrid Forms to Parallel Forms of Human Telomeric G-quadruplexes.
Zi-Fu Wang, et al. Nucleic Acids Res. 2016 May 5;44(8):3958-68. PMID: 26975658.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: BMVC-8C3O supplier, DNA/RNA Synthesis, inhibitors

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