Free shipping on all orders over $ 500

BMS-986205

Cat. No. M6248
BMS-986205 Structure
Size Price Availability Quantity
5mg USD 180 In stock
10mg USD 330 In stock
50mg USD 750 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

BMS-986205 is a selective indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 410.91
Formula C24H24ClFN2O
CAS Number 1923833-60-6
Purity >98%
Solubility 10 mM in DMSO
Storage at -20°C
References

Blocking IDO1 Helps Shrink Bladder, Cervical Tumors.
Cancer Discov. 2018 Jan;8(1):OF3. PMID: 29167110.

Related Products
LB-100

LB-100 is a water soluble protein phosphatase 2A (PP2A) inhibitor, with IC50 of 0.85 μM and 3.87 μM in BxPc-3 and Panc-1 cells.

Compstatin

Compstatinis is a 13-residue cyclic peptide, binds to complement component C3 and inhibits complement activation with IC50 of 12 μM.

Azaserine

Azaserine is an inhibitor of the rate limiting step of the hexosamine biosynthethic pathway (HBP) and an irreversible inhibitor of GGT1 (gamma-Glutamyltranspeptidase).

TM6008

TM6008 is a novel PHD inhibitor, which inhibited PHD and stabilized HIF activity in vitro.

ASP9521

ASP9521 is a novel, selective, orally bioavailable inhibitor of 17β-hydroxysteroid dehydrogenase type 5 (17βHSD5; AKR1C3).

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: BMS-986205 supplier, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.