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BMS-986205

Cat. No. M6248
BMS-986205 Structure
Size Price Availability Quantity
5mg USD 180 In stock
10mg USD 330 In stock
50mg USD 750 In stock
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Quality Control
  • Current batch:
  • Purity > 99%
  • COA
  • MSDS
Biological Activity

BMS-986205 is a selective indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 410.91
Formula C24H24ClFN2O
CAS Number 1923833-60-6
Purity > 99%
Solubility 10 mM in DMSO
Storage at -20°C
References

Blocking IDO1 Helps Shrink Bladder, Cervical Tumors.
Cancer Discov. 2018 Jan;8(1):OF3. PMID: 29167110.

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  Catalog
Abmole Inhibitor Catalog 2017




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