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BMS-345541

Cat. No. M2462
BMS-345541 Structure
Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
5mg USD 105 In stock
25mg USD 300 In stock
50mg USD 500 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
Biological Activity

BMS-345541 is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM, respectively.

Customer Product Validations & Biological Datas
Source Eye Vis (Lond) (2017). Figure 1. BMS-345541
Method SEAP assay
Cell Lines HCET cells
Concentrations -
Incubation Time 24 h
Results SEAP assay showed that both Wedelolactone and BMS-345541 could significantly inhibit Pam3CSK4-induced NF-κB activity
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 255.32
Formula C14H17N5
CAS Number 445430-58-0
Purity >99%
Solubility DMSO
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: BMS-345541 supplier, IκB/IKK, inhibitors

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