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BMS-345541 hydrochloride

Cat. No. M2336

BMS-345541 hydrochloride Structure
Size Price Availability Quantity
10mg USD 180 In stock
50mg USD 660 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

BMS-345541 hydrochloride is an anti-inflammatory, cell-permeable quinoxaline compound with a highly selective IKKbeta inhibitory activity. BMS-345541 blocks both joint inflammation and destruction in collagen-induced arthritis in mice. BMS-345541 hydrochloride induced apoptosis and an accumulation of cells in the G 2/M phase of the cell cycle via inhibition of IKK/NFκB signaling. T-ALL cells treated with BMS-345541 displayed nuclear translocation of FOXO3a and restoration of its functions, including control of p21(Cip1) expression levels. BMS-345541 hydrochloride is an allosteric site-binding inhibitor with a primary target of IKK-2 and blocks the NF-κB-dependent transcription in mice.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 291.78
Formula C14H17N5.HCl
CAS Number 547757-23-3
Purity >99%
Solubility DMSO
Water
Storage at -20°C
References

Activity of the selective IκB kinase inhibitor BMS-345541 against T-cell acute lymphoblastic leukemia: involvement of FOXO3a.
Buontempo F, et al. Cell Cycle. 2012 Jul 1;11(13):2467-75. PMID: 22713244.

BMS-345541 targets inhibitor of kappaB kinase and induces apoptosis in melanoma: involvement of nuclear factor kappaB and mitochondria pathways.
Yang J, et al. Clin Cancer Res. 2006 Feb 1;12(3 Pt 1):950-60. PMID: 16467110.

A highly selective inhibitor of I kappa B kinase, BMS-345541, blocks both joint inflammation and destruction in collagen-induced arthritis in mice.
McIntyre KW, et al. Arthritis Rheum. 2003 Sep;48(9):2652-9. PMID: 13130486.

BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice.
Burke JR, et al. J Biol Chem. 2003 Jan 17;278(3):1450-6. PMID: 12403772.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: BMS-345541 hydrochloride supplier, IκB/IKK, inhibitors

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