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BMS-3

Cat. No. M6144
BMS-3  Structure
Size Price Availability Quantity
5mg USD 95 In stock
10mg USD 150 In stock
50mg USD 430 In stock
100mg USD 720 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

To understand the physiological implication of inhibiting the LIMK/Cofilin signaling pathway in sperm physiology, we demonstrated that inhibition of pLIMK1 with BMS-3 resulted in low levels of F-actin. What is the relative contribution of RhoA/C and Rac1 during capacitation is still unknown. Another important aspect to determine is how the LIMK1/Cofilin signaling pathway interacts with PLD1, which was shown to be essential for actin polymerization in bovine sperm. One interesting possibility is that pCofilin stimulates PLD1 activity as demonstrated recently

Protocol
Cell Experiment
Cell lines
Preparation method
Concentrations
Incubation time
Animal Experiment
Animal models
Formulation
Dosages
Administration
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 429.27
Formula C17H12Cl2F2N4OS
CAS Number 1338247-30-5
Purity >99%
Solubility 30 mg/mL in DMSO
Storage at -20°C
References

PKA-dependent phosphorylation of LIMK1 and Cofilin is essential for mouse sperm acrosomal exocytosis.
Romarowski A, et al. Dev Biol. 2015 Sep 15;405(2):237-49. PMID: 26169470.

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  Catalog
Abmole Inhibitor Catalog 2017




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