BMS-265246 is a potent and selective CDK1/CDK2 selective inhibitor for CDK1/cycB and CDK2/cycE with IC50 of 6 and 9 nM, respectively. BMS-265246 inhibits the activity of CDK4/cycD with an IC50 of 0.23 μM and prevents A2780 Cytox with an IC50 of 0.76μM. BMS-265246 exhibits CDK1 and CDK2 potency that is 25- and 11-fold more potent versus CDK1 and CDK2, respectively.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||DMSO 20 mg/mL|
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