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BMS-265246

Cat. No. M2323

BMS-265246 Structure
Size Price Availability Quantity
10mg USD 330 In stock
50mg USD 950 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

BMS-265246 is a potent and selective CDK1/CDK2 selective inhibitor for CDK1/cycB and CDK2/cycE with IC50 of 6 and 9 nM, respectively. BMS-265246 inhibits the activity of CDK4/cycD with an IC50 of 0.23 μM and prevents A2780 Cytox with an IC50 of 0.76μM. BMS-265246 exhibits CDK1 and CDK2 potency that is 25- and 11-fold more potent versus CDK1 and CDK2, respectively.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 345.34
Formula C18H17F2N3O2
CAS Number 582315-72-8
Purity >99%
Solubility DMSO 20 mg/mL
Storage at -20°C
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RO-3306

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: BMS-265246 supplier, CDK, inhibitors

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