Molecular weight: about 15.7 kDa
Endotoxin <0.2 EU/μg was determined by LAL method.
Composition: lyophilized after extensive dialysis in 30% acetonitrile, 0.1% TFA solution.
Purity: SDS-PAGE > 95% HPLC analysis of 95%
Stability and storage: store at -20°C. After recombination, it can be stabilized at 4℃ for 1 week or -20℃ for a longer time. It is recommended to freeze storage at -20 ° C or -80 ° C to prolong storage time.
Biological activity: Bone Morphogenetic protein-7 (BMP-7) (E. coli) is a homodimer glycoprotein belonging to the transforming growth factor β (TGFβ) superfamily, which plays a role in osteogenesis and chondrogenesis. It is involved in a variety of cellular processes including kidney and eye development, brown fat formation and bone metastasis.
| Solubility (25°C) | Reconstitute the lyophilized powder in 10 mM HAc to a concentration of 0.1-1.0 mg/mL |
| Storage | Stable for up to 6 months at -70°C or -20°C after receipt |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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