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Fisogatinib (BLU-554)

Cat. No. M5237
Fisogatinib (BLU-554) Structure
Synonym:

BLU554; Fisogatinib

Size Price Availability Quantity
5mg USD 145  USD145 In stock
10mg USD 240  USD240 In stock
50mg USD 750  USD750 In stock
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Quality Control & Documentation
Biological Activity

In vitro:Fisogatinib (BLU-554) exploits a unique interaction with FGFR4 to confer potency and selectivity.

In vivo: Fisogatinib (BLU-554) is well tolerated in these tumor models. Administration of Fisogatinib (BLU-554) induces tumor regression in liver cancer models.

Chemical Information
Molecular Weight 503.38
Formula C24H24Cl2N4O4
CAS Number 1707289-21-1
Solubility (25°C) 100 mg/mL in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Hagel M, et al. Cancer Discov. First Selective Small Molecule Inhibitor of FGFR4 for the Treatment of Hepatocellular Carcinomas with an Activated FGFR4 Signaling Pathway.

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Keywords: Fisogatinib (BLU-554), BLU554; Fisogatinib supplier, FGFR, inhibitors, activators


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