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Bleomycin A5 Hydrochloride

Cat. No. M9860
Bleomycin A5 Hydrochloride Structure
Synonym:

BLEOCIN Antibiotic; Bleomycin A5 HCl

Size Price Availability Quantity
10mg USD 250  USD250 In stock
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Quality Control & Documentation
Biological Activity

Bleomycin A5 Hydrochloride is a unique antibiotic of the bleomycin family that is toxic to eukaryotic and prokaryotic cells. BLEOCIN Antibiotic cleaves double-stranded DNA and inhibits DNA synthesis, resulting in cell death. Bleomycin A5 Hydrochloride can be used for selection of recombinant clones in a variety of cell types transfected with vectors containing a ble resistance marker.

Chemical Information
Molecular Weight 1477.04
Formula C57H89N19O21S2.x(HCl)
CAS Number 55658-47-4
Solubility (25°C) Water ≥ 10 mg/mL
Storage -20°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Keyun Shi, et al. Int J Clin Exp Med. Dexamethasone attenuates bleomycin-induced lung fibrosis in mice through TGF-β, Smad3 and JAK-STAT pathway

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Keywords: Bleomycin A5 Hydrochloride, BLEOCIN Antibiotic; Bleomycin A5 HCl supplier, DNA/RNA Synthesis, inhibitors, activators


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