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Bis(triphenylphosphine)palladium(II) dichloride

Cat. No. M9660
Bis(triphenylphosphine)palladium(II) dichloride Structure
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Biological Activity

Bis(triphenylphosphine)palladium(II) dichloride

Chemical Information
Molecular Weight 701.9
Formula C36H30Cl2P2Pd
CAS Number 13965-03-2
Solubility (25°C) Soluble in toluene and benzene
Slightly soluble in acetone and chloroform
Storage 2-8°C, dry, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Stefan Holler, et al. Thiopyridazine-Based Palladium and Platinum Boratrane Complexes

[2] K Hemalatha, et al. Binding mode of dihydroquinazolinones with lysozyme and its antifungal activity against Aspergillus species

[3] Ming Liu, et al. Formation of N-Heterocyclic Carbenes by Tautomerization of Mesomeric Betaines: Cyclic Boron Adducts and Palladium Complexes From 2-(Imidazolium-1-yl)phenolates

[4] Barbara L Walton, et al. Imidazolium salts with varying anions as charge carriers for detection of neutral bis(triphenylphosphine)palladium(II) dichloride in electrospray ionization mass spectrometry

[5] T Djekić, et al. Evaluation of functionalized silica's for the adsorptive recovery of homogenous catalysts through interaction with the metal centre

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