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Olcegepant (BIBN-4096)

Cat. No. M6504
Olcegepant (BIBN-4096) Structure
Synonym:

BIBN-4096; BIBN 4096BS

Size Price Availability Quantity
5mg USD 220  USD220 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

BIBN 4096 (Olcegepant) is a potent and selective CGRP receptor antagonist (IC50 values are 0.03 and 6.4 nM for human and rat CGRP receptors respectively). Displays high affinity for human CGRP receptors (Ki = 14.4 pM); exhibits no significant affinity for 75 other receptors.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 869.65
Formula C38H47Br2N9O5
CAS Number 204697-65-4
Purity >98%
Solubility DMSO 45 mg/mL
Storage at -20°C
References

[1] Paul Kohli, et al. Bone . Effects of CGRP receptor antagonism on glucose and bone metabolism in mice with diet-induced obesity

[2] Benoit Michot, et al. Pain . Differential effects of calcitonin gene-related peptide receptor blockade by olcegepant on mechanical allodynia induced by ligation of the infraorbital nerve vs the sciatic nerve in the rat

[3] Marie-Luise Sixt, et al. Brain . Calcitonin gene-related peptide receptor antagonist olcegepant acts in the spinal trigeminal nucleus

[4] Yamamoto, et al. Biosci Biotechnol Biochem. Antibacterial agents that inhibit histidine protein kinase YycG of Bacillus subtilis.

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Keywords: Olcegepant (BIBN-4096), BIBN-4096; BIBN 4096BS supplier, CGRP Receptor, inhibitors

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