Free shipping on all orders over $ 500


Cat. No. M1673
BIBF1120 Structure


Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mM/1mL In DMSO USD 70 In stock
10mg USD 60 In stock
50mg USD 180 In stock
100mg USD 350 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
Biological Activity

BIBF 1120 is an indolinone derivative potently blocking VEGF receptor (VEGFR), PDGFR and FGFR kinase activity in enzymatic assays (IC50, 20–100 nmol/L). BIBF 1120 inhibits mitogen-activated protein kinase and Akt signaling pathways in three cell types contributing to angiogenesis, endothelial cells, pericytes, and smooth muscle cells, resulting in inhibition of cell proliferation (EC50, 10–80 nmol/L) and apoptosis.

Customer Product Validations & Biological Datas
Source Oncotarget (2015). Figure 5. BIBF1120
Method Western blots
Cell Lines SKOV3 cells
Concentrations 5 μM
Incubation Time 24 h
Results We utilized a custom-made siRNA library for the six mesenchymal signature genes to test the differences in the nintedanib effects on E-cadherin induction
Source Oncotarget (2015). Figure 4. BIBF1120
Method Western blots
Cell Lines SKOV3 cells
Concentrations 5 μM
Incubation Time 24 h
Results Furthermore, 5 μM nintedanib concomitantly up-regulated both E-cadherin protein and CDH1 transcript levels
Cell Experiment
Cell lines HUVEC, HSMEC, BRP, HUASMC, FaDu, Calu-6 and Hela cells line
Preparation method Cell proliferation and apoptosis assays.[3H]Thymidine incorporation assay for proliferation analysis and apoptosis assay was performed as previously described.
Concentrations 0~5µM
Incubation time 72 h
Animal Experiment
Animal models Human FaDu (squamous cell carcinoma of the head and neck) xenografts growing in nude mice
Formulation not mentioned
Dosages 10, 50, 100 mg/kg
Administration orally
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 539.62
Formula C31H33N5O4
CAS Number 928326-83-4, 656247-17-5
Purity 99.46%
Solubility DMSO
Storage at -20°C

Chemotherapy plus multitargeted antiangiogenic tyrosine kinase inhibitors or chemotherapy alone in advanced NSCLC: a meta-analysis of randomized controlled trials.
Xiao et al. Eur J Clin Pharmacol. 2012 Jun 24. PMID: 22729611.

Unravelling the progressive pathophysiology of idiopathic pulmonary fibrosis.
Günther et al. Eur Respir Rev. 2012 Jun 1;21(124):152-60. PMID: 22654088.

A phase I, open-label dose-escalation study of continuous treatment with BIBF 1120 in combination with paclitaxel and carboplatin as first-line treatment in patients with advanced non-small-cell lung cancer.
Doebele et al. Ann Oncol. 2012 Aug;23(8):2094-102. PMID: 22345119.

New antiangiogenics in non-small cell lung cancer treatment: Vargatef™ (BIBF 1120) and beyond.
Gori et al. Ther Clin Risk Manag. 2011;7:429-40. PMID: 22241943.

Phase I study of BIBF 1120 with docetaxel and prednisone in metastatic chemo-naive hormone-refractory prostate cancer patients.
Bousquet et al. Br J Cancer. 2011 Nov 22;105(11):1640-5. PMID: 22027711.

Related VEGFR/PDGFR Products
EG00229 Trifluoroacetate salt

EG00229 Trifluoroacetate is the first small molecule inhibitor of the neuropilin-1 and VEGF-A interaction with an IC50 of inhibition of 8 uM (125I-VEGF binding to PAE/NRP1 cells).


Apatinib is a selective VEGFR2 inhibitor with IC50 of 1 nM.


JI-101 is an orally available multi-kinase inhibitor of VEGFR2,PDGFRβ and EphB4 with potential antiangiogenic and antineoplastic activities.


BAW2881 (NVP-BAW2881) is a potent and selective VEGFR2 inhibitor with activity to inhibit chronic and acute skin inflammation.


SU 1498 is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2 (VEGFR2, aka FLK1; IC50 = 700 nM).

Abmole Inhibitor Catalog 2017

Keywords: BIBF1120, Vargatef supplier, VEGFR/PDGFR, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.