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Bethanechol chloride

Cat. No. M3309
Bethanechol chloride Structure
Synonym:

Carbamyl-β-methylcholine chloride

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
100mg USD 39  USD39 In stock
200mg USD 53  USD53 In stock
1g USD 63  USD63 In stock
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Quality Control & Documentation
Biological Activity

Bethanechol chloride is a selective muscarinic receptor agonist without any effect on nicotinic receptors. It is a parasympathomimetic choline ester. It is not hydrolyzed by cholinesterase and will therefore have a long duration of action. It does not involve the action of the muscarinic M3 receptor subtype in-vitro.

Chemical Information
Molecular Weight 196.68
Formula C7H17N2O2.Cl
CAS Number 590-63-6
Solubility (25°C) DMSO 20 mg/mL
Water 30 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Shivani Gaitonde, et al. Bethanechol: Is it still being prescribed for bladder dysfunction in women?

[2] Tarinee Manchana, et al. Bethanechol chloride for the prevention of bladder dysfunction after radical hysterectomy in gynecologic cancer patients: a randomized controlled trial study

[3] J L Schlatter, et al. Bethanechol chloride oral solutions: stability and use in infants

[4] J K Light, et al. Bethanechol chloride and the traumatic cord bladder

[5] A E Finkbeiner. Is bethanechol chloride clinically effective in promoting bladder emptying? A literature review

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