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β-Endorphin (27-31) (human)

Cat. No. M9935
β-Endorphin (27-31) (human) Structure
Synonym:

TYR-LYS-LYS-GLY-GLU

Size Price Availability
10mg USD 240  USD240 1-2 Weeks
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Quality Control & Documentation
Biological Activity

H-Tyr-Lys-Lys-Gly-Glu-OH; b-Endorphin (27-31) (human); TYR-LYS-LYS-GLY-GLU; β-Endorphin (27-31) (human)

Chemical Information
Molecular Weight 683.755
Formula C28H45N7O9.C2H4O2
CAS Number 77875-70-8
Solubility (25°C) Soluble in water
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] A Menzebach, et al. Effects of endogenous and synthetic opioid peptides on neutrophil function in vitro

[2] L Schweigerer, et al. Interaction of human beta-endorphin with nonopiate binding sites on the terminal SC5b-9 complex of human complement. Significance of COOH-terminal beta H-endorphin fragments

[3] C Tzougraki, et al. Synthesis of human beta-endorphin in solution using benzyl-type side chain protective groups

[4] W O Richter, et al. In vitro lipolytic activity of beta-endorphin and its partial sequences

[5] P Schotman-Schram, et al. Stress in newborn infants: a literature review

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