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β-Aminopropionitrile (Liquid)

Cat. No. M10552
β-Aminopropionitrile (Liquid) Structure
Synonym:

3-Aminopropionitrile

Size Price Availability Quantity
1g USD 40  USD40 In stock
5g USD 100  USD100 In stock
10g USD 140  USD140 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

β-Aminopropionitrile is a specific and irreversible lysyl oxidase (LOX) inhibitor. β-Aminopropionitrile blocks the hypoxia-induced EMT morphological and marker protein changes, and inhibited invasion and migration capacities of cervical carcinoma cells in vitro.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 70.09
Formula C3H6N2
CAS Number 151-18-8
Purity >99%
Solubility DMSO 100 mg/mL
Water 50 mg/mL
Storage 2-8°C, protect from light, sealed
References

[1] Maria Miana, et al. Dis Model Mech. The lysyl oxidase inhibitor β-aminopropionitrile reduces body weight gain and improves the metabolic profile in diet-induced obesity in rats

[2] Xiaoxiao Yang, et al. Oncol Rep. Inactivation of lysyl oxidase by β-aminopropionitrile inhibits hypoxia-induced invasion and migration of cervical cancer cells

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Keywords: β-Aminopropionitrile (Liquid), 3-Aminopropionitrile supplier, inhibitors

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