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β-Aminopropionitrile (Liquid)

Cat. No. M10552
β-Aminopropionitrile (Liquid) Structure
Synonym:

3-Aminopropionitrile

Size Price Availability Quantity
1g USD 40  USD40 In stock
5g USD 100  USD100 In stock
10g USD 140  USD140 In stock
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Quality Control & Documentation
Biological Activity

β-Aminopropionitrile is a specific and irreversible lysyl oxidase (LOX) inhibitor. β-Aminopropionitrile blocks the hypoxia-induced EMT morphological and marker protein changes, and inhibited invasion and migration capacities of cervical carcinoma cells in vitro.

Chemical Information
Molecular Weight 70.09
Formula C3H6N2
CAS Number 151-18-8
Solubility (25°C) DMSO 100 mg/mL
Water 50 mg/mL
Storage 2-8°C, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Maria Miana, et al. Dis Model Mech. The lysyl oxidase inhibitor β-aminopropionitrile reduces body weight gain and improves the metabolic profile in diet-induced obesity in rats

[2] Xiaoxiao Yang, et al. Oncol Rep. Inactivation of lysyl oxidase by β-aminopropionitrile inhibits hypoxia-induced invasion and migration of cervical cancer cells

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Keywords: β-Aminopropionitrile (Liquid), 3-Aminopropionitrile supplier, Animal Modeling, inhibitors, activators


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