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Cat. No. M4770
Berberrubine Structure
Size Price Availability Quantity
20mg USD 380 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity


Customer Product Validations & Biological Datas
Source Asian Pac J Cancer Prev (2015). Figure 4. Berberrubine
Method DPPH assay
Cell Lines HT1080 cells
Concentrations 0.1 and 1.0 μM
Incubation Time 7 d
Results In contrast, B2-B4 did not show the significant difference in CAT expression if compared with B1. Interestingly, compounds B1-B4 exhibited a significant up-regulation of SOD expression in a dose dependent fashion (p<0.05) compared with the untreated cells.
Source Asian Pac J Cancer Prev (2015). Figure 3. Berberrubine
Method MTT assay
Cell Lines HT1080 cells
Concentrations 0.1 and 1.0 μM
Incubation Time 7 d
Results The result of cytotoxicity (Figure 3) showed that compounds B1, B2, and B4 significantly decreased the viability of HT1080 at all concentrations with both dose and time-dependent fashion (p<0.05).
Cell Experiment
Cell lines AMC5 cells
Preparation method AMC5/B1 cells were selected by intermittent exposure of surviving cells to increasing concentrations of berberrubine. AMC5 cells in 100-mm plastic dishes were first exposed to berberrubine at 10 μM to reduce the surviving fraction to 20 to 30% and were allowed to grow in the absence of selecting drug until they reached the initial cell density or greater.
Concentrations 10 μM
Incubation time 16 h
Animal Experiment
Animal models C57BL/6J mice
Dosages 25, 50 mg/kg
Administration p.o.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 321.33
Formula C19H15NO4
CAS Number 15401-69-1
Purity >98%
Storage at -20°C

High fat diet aggravates the nephrotoxicity of berberrubine by influencing on its pharmacokinetic profile.
Yang N, et al. Environ Toxicol Pharmacol. 2016 Sep;46:319-327. PMID: 27525563.

Down-regulation of DNA topoisomerase IIalpha in human colorectal carcinoma cells resistant to a protoberberine alkaloid, berberrubine.
Kang MR, et al. Mol Pharmacol. 2002 Apr;61(4):879-84. PMID: 11901227.

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