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Benzyl isothiocyanate

Cat. No. M9156
Benzyl isothiocyanate Structure
Synonym:

Isothiocyanic Acid Benzyl Ester

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Biological Activity

Benzyl isothiocyanate is a naturally-occurring constituent of cruciferous vegetables with antibacterial properties. Benzyl isothiocyanate (BITC) is highly effective in suppressing cancer initiation by modulating carcinogen-activating (phase I) and -detoxifying (phase II) enzymes during initiation events of tumor growth. BITC inhibits chemically induced cancer, oncogenic-driven tumor formation, and human tumor xenografts in rodent cancer models. It decreases pulmonary metastasis multiplicity and volume of 4T1 murine mammary carcinoma cells injected into the inguinal mammary fat pads of syngeneic female BALB/c mice.

Chemical Information
Molecular Weight 149.21
Formula C8H7NS
CAS Number 622-78-6
Form Liquid
Solubility (25°C) DMSO: 25 mg/mL
Storage 2-8°C, dry, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Rao CV. Cancer Prev Res (Phila). Benzyl isothiocyanate: double trouble for breast cancer cells.

[2] Zhang R, et al. J Nutr. Benzyl isothiocyanate-induced DNA damage causes G2/M cell cycle arrest and apoptosis in human pancreatic cancer cells.

[3] Sticha KR, et al. Carcinogenesis. Effects of benzyl isothiocyanate and phenethyl isothiocyanate on benzo[a]pyrene metabolism and DNA adduct formation in the A/J mouse.

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Keywords: Benzyl isothiocyanate, Isothiocyanic Acid Benzyl Ester supplier, Antibiotic, inhibitors, activators


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