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Benzyl isothiocyanate

Cat. No. M9156
Benzyl isothiocyanate Structure
Synonym:

Isothiocyanic Acid Benzyl Ester

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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Benzyl isothiocyanate is a naturally-occurring constituent of cruciferous vegetables with antibacterial properties. Benzyl isothiocyanate (BITC) is highly effective in suppressing cancer initiation by modulating carcinogen-activating (phase I) and -detoxifying (phase II) enzymes during initiation events of tumor growth. BITC inhibits chemically induced cancer, oncogenic-driven tumor formation, and human tumor xenografts in rodent cancer models. It decreases pulmonary metastasis multiplicity and volume of 4T1 murine mammary carcinoma cells injected into the inguinal mammary fat pads of syngeneic female BALB/c mice.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 149.21
Formula C8H7NS
CAS Number 622-78-6
Purity >98%
Solubility DMSO: 25 mg/mL
Storage 2-8°C, dry, protect from light
References

Benzyl isothiocyanate: double trouble for breast cancer cells.
Rao CV. Cancer Prev Res (Phila). 2013 Aug;6(8):760-3. PMID: 23842793.

Benzyl isothiocyanate-induced DNA damage causes G2/M cell cycle arrest and apoptosis in human pancreatic cancer cells.
Zhang R, et al. J Nutr. 2006 Nov;136(11):2728-34. PMID: 17056792.

Effects of benzyl isothiocyanate and phenethyl isothiocyanate on benzo[a]pyrene metabolism and DNA adduct formation in the A/J mouse.
Sticha KR, et al. Carcinogenesis. 2000 Sep;21(9):1711-9. PMID: 10964103.

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Keywords: Benzyl isothiocyanate, Isothiocyanic Acid Benzyl Ester supplier, inhibitors

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