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Benzolamide

Cat. No. M10307
Benzolamide Structure
Synonym:

CL-11366; W-1803

Size Price Availability Quantity
25mg USD 200  USD200 In stock
50mg USD 300  USD300 In stock
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Quality Control & Documentation
Biological Activity

Benzolamide is a carbonic anhydrase inhibitor. Benzolamide inhibits low-threshold calcium currents in hippocampal pyramidal neurons. Benzolamide improves oxygenation and reduces acute mountain sickness during a high-altitude trek and has fewer side effects than acetazolamide at sea level. Benzolamide perpetuates acidic conditions during reperfusion and reduces myocardial ischemia-reperfusion injury.

Chemical Information
Molecular Weight 320.36
Formula C8H8N4O4S3
CAS Number 3368-13-6
Solubility (25°C) Water 0.3 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Luisa F Gonzalez Arbelaez, et al. Exp Mol Pathol. Cardioprotection of benzolamide in a regional ischemia model: Role of eNOS/NO

[2] Alejandro Ciocci Pardo, et al. J Appl Physiol. Benzolamide perpetuates acidic conditions during reperfusion and reduces myocardial ischemia-reperfusion injury

[3] T H Maren, et al. Johns Hopkins Med J. The teratological effect of benzolamide, a new carbonic anhydrase inhibitor

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Keywords: Benzolamide, CL-11366; W-1803 supplier, inhibitors, activators


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