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BCTC

Cat. No. M6494
BCTC Structure
Size Price Availability Quantity
10mg USD 120 In stock
50mg USD 400 In stock
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Quality Control
Biological Activity

BCTC is a orally effective vanilloid receptor 1 (TRPV1 receptor) antagonist. Inhibits acid- and capsaicin-induced activation of rat TRPV1 receptors (IC50 values are 6.0 and 35 nM respectively). Displays analgesic properties in rat models of inflammatory and neuropathic pain. CNS penetrant.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 372.89
Formula C20H25ClN4O
CAS Number 393514-24-4
Purity 99.96%
Solubility DMSO ≥ 38 mg/mL
Storage at -20°C
References

Activity of cytisine and its brominated isoteres on recombinant human α7, α4β2 and α4β4 nicotinic acetylcholine receptors.
Houlihan, et al. J Neurochem. 2001;78: 1029. PMID: 11553677.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: BCTC supplier, TRP Channel, inhibitors

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