Bambuterol hydrochloride is a potent β2-adrenoceptor agonist. Bambuterol hydrochloride is a selective butyrylcholinesterase inhibitor. Bambuterol hydrochloride shows bronchodilatory and anti-allodynic effects in vivo. Bambuterol hydrochloride is orally active.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
Effects of bambuterol and terbutaline on isolated rat's tracheal smooth muscle.
Chou YL, et al. Eur Arch Otorhinolaryngol. 2010 Aug;267(8):1305-11. PMID: 20012638.
Amino acid residues involved in stereoselective inhibition of cholinesterases with bambuterol.
Bosak A, et al. Arch Biochem Biophys. 2008 Mar 1;471(1):72-6. PMID: 18167304.
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