Baicalin facilitated the transfer of electrons from Fe (2+) to dissolved oxygen.Baicalin has the capacity to protect IEC-6 cells and the intercellular tight junctions from LPS-induced injury.The mechanisms may be associated with inhibiting the production of inflammatory cytokines,and up-regulating the mRNA and protein expression of ZO-1.baicalin had no effects on the pharmacokinetics of caffeine and its metabolites in vivo,following single oral administration in rats.Anti-inflammatory properties of baicalin may be resulted from the inhibition of IL-6, IL-8, and TNF-α expression via preventing signaling NF-κB pathway in HBE16 airway epithelial cells.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
Effects of baicalin on oral pharmacokinetics of caffeine in rats.
Noh K, et al. Biomol Ther (Seoul). 2015 Mar;23(2):201-6. PMID: 25767690.
Protective effects of baicalin on LPS-induced injury in intestinal epithelial cells and intercellular tight junctions.
Chen J, et al. Can J Physiol Pharmacol. 2015 Apr;93(4):233-7. PMID: 25665915.
Baicalin inhibits the fenton reaction by enhancing electron transfer from fe (2+) to dissolved oxygen.
Nishizaki D, et al. Am J Chin Med. 2015;43(1):87-101. PMID: 25640849.
Baicalin Inhibits Lipopolysaccharide-Induced Inflammation Through Signaling NF-κB Pathway in HBE16 Airway Epithelial Cells.
Dong SJ, et al. Inflammation. 2015 Jan 30. PMID: 25630720.
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