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Azithromycin Dihydrate

Cat. No. M2426
Azithromycin Dihydrate Structure
Synonym:

CP-62993 dihydrate

Size Price Availability Quantity
10mg USD 45  USD45 In stock
50mg USD 90  USD90 In stock
100mg USD 135  USD135 In stock
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Quality Control & Documentation
Biological Activity

Azithromycin Dihydrate is an acid stable orally administered macrolide antimicrobial drug, structurally related to erythromycin.The clinical efficacy of azithromycin has been confirmed in the treatment of infections of the lower and upper respiratory tracts (the latter including paediatric patients), skin and soft tissues (again including paediatric patients), in uncomplicated urethritis/cervicitis associated with N. gonorrhoeae, Chlamydia trachomatis or U. urealyticum and in the treatment of early Lyme disease. Azithromycin was as effective as erythromycin and quinolone and tetracycline antibiotics in some of the above infections.

Product Citations
Chemical Information
Molecular Weight 785.02
Formula C38H72N2O12.2H2O
CAS Number 117772-70-0
Solubility (25°C) DMSO: ≥ 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Peters DH, et al. Drugs Azithromycin. A review of its antimicrobial activity, pharmacokinetic properties and clinical efficacy.

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