Free shipping on all orders over $ 500

AZD8848

Cat. No. M10790
AZD8848  Structure
Size Price Availability Quantity
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

AZD8848 is a selective TLR7 precursor drug agonist for the study of asthma and allergic rhinitis.

Chemical Information
Molecular Weight 569.69562
Formula C29H43N7O5
CAS Number 866269-28-5
Solubility (25°C) DMSO ≥ 20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Brian R Leaker, et al. Respir Res. Effects of the Toll-like receptor 7 (TLR7) agonist, AZD8848, on allergen-induced responses in patients with mild asthma: a double-blind, randomised, parallel-group study

[2] Stephen Delaney, et al. BMJ Open Respir Res. Tolerability in man following inhalation dosing of the selective TLR7 agonist, AZD8848

[3] Zahra Aryan, et al. Curr Opin Allergy Clin Immunol. Toll-like receptors as targets for allergen immunotherapy

[4] Lennart Greiff, et al. Inflamm Res. Biological effects and clinical efficacy of a topical Toll-like receptor 7 agonist in seasonal allergic rhinitis: a parallel group controlled phase IIa study

[5] Lennart Greiff, et al. Respir Res. Repeated intranasal TLR7 stimulation reduces allergen responsiveness in allergic rhinitis

Related TLR Products
Kdo2-Lipid A ammonium

Kdo2-Lipid A ammonium is a chemically defined lipopolysaccharide (LPS) with endotoxic activity equivalent to LPS.Kdo2-Lipid A ammonium is highly selective for TLR4 and stimulates the release of TNF and PGE2.

PSMα3

PSMα3 is a peptide for manipulating DCs to become tolerogenic for DC vaccination strategies.

Pam2CSK4

Pam2CSK4, a lipopeptide, is a TLR6-independent TLR2 ligand and agonist.

MAPK-IN-1

MAPK-IN-1 is a MAPK signaling pathway inhibitor.

Cobitolimod

Cobitolimod is a first-of-its-kind (first-in-class), synthetic oligodeoxynucleotide (ODN) containing unmethylated CpG motifs that activates TLR9 in specific cells, including intestinal T and B lymphocytes as well as antigen-presenting cells (APCs), and can be used in studies related to inflammatory bowel disease (IBD).

  Catalog
Abmole Inhibitor Catalog




Keywords: AZD8848 supplier, TLR, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.