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AZD7507

Cat. No. M10938
AZD7507  Structure
Size Price Availability Quantity
5mg USD 190  USD190 In stock
10mg USD 340  USD340 In stock
50mg USD 1020  USD1020 In stock
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Quality Control & Documentation
Biological Activity

AZD7507 is a potent, oral CSF-1R inhibitor with antitumor activity.

Chemical Information
Molecular Weight 454.5
Formula C23H27FN6O3
CAS Number 1041852-85-0
Solubility (25°C) DMSO ≥ 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Juliana B Candido, et al. Cell Rep. CSF1R + Macrophages Sustain Pancreatic Tumor Growth through T Cell Suppression and Maintenance of Key Gene Programs that Define the Squamous Subtype

[2] Luke Boulter, et al. J Clin Invest. WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited

[3] David A Scott, et al. Bioorg Med Chem Lett. Mitigation of cardiovascular toxicity in a series of CSF-1R inhibitors, and the identification of AZD7507

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  Catalog
Abmole Inhibitor Catalog




Keywords: AZD7507 supplier, CSF-1R (c-Fms), inhibitors, activators


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