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AZD5582

Cat. No. M10702
AZD5582 Structure
Size Price Availability Quantity
5mg USD 110  USD110 In stock
10mg USD 200  USD200 In stock
25mg USD 330  USD330 In stock
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Quality Control & Documentation
Biological Activity

AZD5582 is an IAP antagonist that can be effectively combined with bir3 domains of cIAP1, cIAP2, and XIAP, IC50 The values are 15, 21, 15 nM, respectively. AZD5582 Induces apoptosis.

Chemical Information
Molecular Weight 1015.29
Formula C58H78N8O8
CAS Number 1258392-53-8
Solubility (25°C) DMSO ≥ 20 mg/mL
Storage 2-8°C, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Chaohong Huang, et al. Acta Histochem. Sensitizing TRAIL response via differential modulation of anti- and pro-apoptotic factors by AZD5582 combined with ER nanosomal TRAIL in neuroblastoma

[2] Huan Hou, et al. Adv Healthc Mater. TRAIL-Armed ER Nanosomes Induce Drastically Enhanced Apoptosis in Resistant Tumor in Combination with the Antagonist of IAPs (AZD5582)

[3] Maud Mavigner, et al. J Virol. CD8 lymphocyte depletion enhances the latency reversal activity of the SMAC mimetic AZD5582 in ART-suppressed SIV-infected rhesus macaques

[4] Christopher C Nixon, et al. Nature. Systemic HIV and SIV latency reversal via non-canonical NF-κB signalling in vivo

[5] Lorenz Kadletz, et al. Acta Otolaryngol. AZD5582, an IAP antagonist that leads to apoptosis in head and neck squamous cell carcinoma cell lines and is eligible for combination with irradiation

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  Catalog
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Keywords: AZD5582 supplier, IAP, inhibitors, activators


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