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AZD4635

Cat. No. M7531
AZD4635 Structure
Synonym:

HTL1071

Size Price Availability Quantity
10mg USD 175 In stock
50mg USD 600 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

AZD4635 is a novel adenosine 2A receptor (A2AR) inhibitor with a Ki of 1.7 nM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 315.73
Formula C15H11ClFN5
CAS Number 1321514-06-0
Purity >98%
Solubility 10 mM in DMSO
Storage at -20°C
References

Preclinical pharmacodynamics and antitumor activity of AZD4635, a novel adenosine 2A receptor inhibitor that reverses adenosine mediated T cell suppression
Alexandra Borodovsky, et al. Cancer Research 2017 July;Volume 77, Issue 13 .

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: AZD4635, HTL1071 supplier, Adenosine Receptor, inhibitors

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