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AZD2014

Cat. No. M2299
AZD2014 Structure
Size Price Availability Quantity
10mg USD 120 In stock
50mg USD 340 In stock
100mg USD 575 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

AZD2014 is a novel dual mTORC1 and mTORC2 inhibitor with potential antineoplastic activity. AZD2014 inhibits biomarkers pAKTSer473 and pNDRG1Thr346. AZD2014 has broad antiproliferative activity across multiple tumour cell lines. AZD2014 induces growth inhibition and cell death in breast cancer cell lines, including ER+ cell lines with acquired resistance to hormone therapy. AZD2014 induces tumour growth inhibition against several xenograft models including a human primary explant model of ER+ breast cancer refractory to tamoxifen.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 462.54
Formula C25H30N6O3
CAS Number 1009298-59-2
Purity >99%
Solubility DMSO 20 mg/mL
Storage at -20°C
Customer Product Validations & Biological Datas
Source Cell Physiol Biochem (2018). Figure 4. AZD2014
Method Flow cytometric analysis
Cell Lines NSCLC cell
Concentrations -
Incubation Time 24 h
Results When mTOR was inhibited in anti-miR-99a-A549 cells by AZD2014, the cells became more sensitive to radiation than control cells and the levels of anti-apoptosis markers were reduced
Rating
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: AZD2014 supplier, mTOR, inhibitors

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