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AZD-7594

Cat. No. M6294
AZD-7594 Structure
Synonym:

AZ13189620

Size Price Availability Quantity
5mg USD 240  USD240 In stock
10mg USD 450  USD450 In stock
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Quality Control & Documentation
Biological Activity

AZD7594 is an inhaled, nonsteroidal, potent, and selective modulator of the glucocorticoid receptor (GR). It is being developed for once-daily treatment of chronic obstructive pulmonary disease and asthma, either alone or in combination with a bronchodilator.

Chemical Information
Molecular Weight 606.627
Formula C32H32F2N4O6
CAS Number 1196509-60-0
Form Solid
Solubility (25°C) 10 mM in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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  Catalog
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