Free shipping on all orders over $ 500

AZD-5069

Cat. No. M9275
AZD-5069 Structure
Size Price Availability Quantity
1mg USD 60 In stock
5mg USD 90 In stock
10mg USD 150 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
Biological Activity

AZD-5069 is a CXCR2 chemokine receptor antagonist and is claimed to be useful in the treatment of inflammatory diseases such as chronic obstructive pulmonary disease (COPD). AZD-5069 was shown to inhibit binding of radiolabeled CXCL8 to human CXCR2 with a pIC50 value of 9.1. Furthermore, AZD-5069 inhibited neutrophil chemotaxis, with a pA2 of approximately 9.6, and adhesion molecule expression, with a pA2 of 6.9, in response to CXCL1.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 476.52
Formula C18H22F2N4O5S2
CAS Number 878385-84-3
Purity 99.97%
Solubility DMSO: ≥ 45 mg/mL
Storage at -20°C
References

Evidence on the identity of the CXCR2 antagonist AZD-5069.
Norman P. Expert Opin Ther Pat. 2013 Jan;23(1):113-7. PMID: 22992174.

Related CXCR Products
VUF11207 fumarate

VUF11207 fumarate is a CXCR7 agonist and a high-potency CXCR7 ligand (pKi=8.1).

JMS-17-2

JMS-17-2 is a potent and selective CX3CR1 antagonist with IC50 of 0.32 nM.

MSX-130

MSX-130 is CXCR4 Antagonist.

MSX-127

MSX-127 (NSC-23026) is a CXCR4 receptor modulator.

AMG 487

AMG 487 is a potent and selective antagonist of chemokine (C-X-C motif) receptor 3 (CXCR3) with IC50 values of 8nM and 8.2nM for I-IP-10 and I-ITAC, respectively.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: AZD-5069 supplier, CXCR, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.