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AZ-33

Cat. No. M9849
AZ-33 Structure
Synonym:

AZ33; LDHA Inhibitor 33

Size Price Availability Quantity
5mg USD 197  USD197 In stock
10mg USD 387  USD387 In stock
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Quality Control & Documentation
Biological Activity

AZ-33 is a potent lactate dehydrogenase A (LDHA) inhibitor with IC50 of 0.5 μM.

Chemical Information
Molecular Weight 497.56
Formula C25H27N3O6S
CAS Number 1370290-34-8
Form Solid
Solubility (25°C) DMSO 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Richard A Ward, et al. J Med Chem. Design and synthesis of novel lactate dehydrogenase A inhibitors by fragment-based lead generation

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  Catalog
Abmole Inhibitor Catalog




Keywords: AZ-33, AZ33; LDHA Inhibitor 33 supplier, LDH, inhibitors, activators


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