Free shipping on all orders over $ 500

Avoralstat

Cat. No. M14532
Avoralstat Structure
Synonym:

BCX4161

Size Price Availability Quantity
5mg USD 147  USD147 In stock
10mg USD 210  USD210 In stock
25mg USD 450  USD450 In stock
50mg USD 680  USD680 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Avoralstat (BCX4161), a potent and orally active plasma kallikrein (PKK) inhibitor, is used for hereditary angioedema research.

Chemical Information
Molecular Weight 513.54
CAS Number 918407-35-9
Solubility (25°C) DMSO 50 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Eldhose Iype, et al. In silico and in vitro assays reveal potential inhibitors against 3CL pro main protease of SARS-CoV-2

[2] Young Joo Sun, et al. Structure-based phylogeny identifies avoralstat as a TMPRSS2 inhibitor that prevents SARS-CoV-2 infection in mice

[3] M A Riedl, et al. Evaluation of avoralstat, an oral kallikrein inhibitor, in a Phase 3 hereditary angioedema prophylaxis trial: The OPuS-2 study

[4] Emel Aygren-Prsn, et al. Prophylaxis of hereditary angioedema attacks: A randomized trial of oral plasma kallikrein inhibition with avoralstat

[5] M Cornpropst, et al. Safety, pharmacokinetics, and pharmacodynamics of avoralstat, an oral plasma kallikrein inhibitor: phase 1 study

Related Serine/Threonine Protease Products
Phe-Pro-Ala-pNA

Phe-Pro-Ala-pNA is a chromogenic substrate of tripeptidyl peptidase.

Dansyl-Glu-Gly-Arg-Chloromethylketone

Dansyl-Glu-Gly-Arg-Chloromethylketone is a protease inhibitor, and inhibits serine/threonine proteases.

Fluorescent Substrate for Subtillsin

Fluorescent Substrate for Subtillsin can be used to detect the enzyme activity of subtillsin.

N-Benzoyl-L-tyrosine p-nitroanilide

N-Benzoyl-L-tyrosine p-nitroanilide is a chymotrypsin substrate.

Urinary Trypsin Inhibitor Fragment

Urinary Trypsin Inhibitor Fragment is a fragment derived from urinary trypsin inhibitor by proteolysis.

  Catalog
Abmole Inhibitor Catalog




Keywords: Avoralstat, BCX4161 supplier, Serine/Threonine Protease, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.