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AVE 0991

Cat. No. M10273
AVE 0991 Structure
Synonym:

AVE0991; AVE-0991

Size Price Availability
5mg USD 285  USD285 Out of stock
10mg USD 430  USD430 Out of stock
25mg USD 700  USD700 Out of stock
50mg USD 1020  USD1020 Out of stock
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Quality Control & Documentation
Biological Activity

AVE 0991 is an orally active agonist of angiotensin-(1-7) receptor with IC50 of 21 nM. AVE 0991 evokes effects similar to Ang-(1-7) on the endothelium. Peak concentrations of NO and O2- release by AVE 0991 sodium salt and Ang-(1-7) (both 10 μM) are not significantly different (NO: 295±20 and 270±25 nM; O2-: 18±2 and 20±4 nM). AVE 0991 (0.58 nmol/g) produces a significant decrease of water diuresis in WT mice compared with vehicle-treated animals (0.06±0.03 mL versus 0.27±0.05; n=9 for each group; P<0.01).

Chemical Information
Molecular Weight 580.72
Formula C29H32N4O5S2
CAS Number 304462-19-9
Solubility (25°C) DMSO 40 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jun Mo, et al. Redox Biol. AVE 0991 attenuates oxidative stress and neuronal apoptosis via Mas/PKA/CREB/UCP-2 pathway after subarachnoid hemorrhage in rats

[2] Anderson J Ferreira, et al. Am J Physiol Heart Circ Physiol. The nonpeptide angiotensin-(1-7) receptor Mas agonist AVE-0991 attenuates heart failure induced by myocardial infarction

[3] Sergio Veloso Brant Pinheiro, et al. Hypertension. Nonpeptide AVE 0991 is an angiotensin-(1-7) receptor Mas agonist in the mouse kidney

[4] Gabriele Wiemer, et al. Hypertension. AVE 0991, a nonpeptide mimic of the effects of angiotensin-(1-7) on the endothelium

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Keywords: AVE 0991, AVE0991; AVE-0991 supplier, Angiotensin Receptor, inhibitors, activators


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