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Avanafil

Cat. No. M2410
Avanafil Structure
Size Price Availability Quantity
100mg USD 130 In stock
500mg USD 440 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Avanafil is a highly selective PDE5 inhibitor with IC50 of 5.2 nM, >121-fold selectivity over other PDEs. Avanafil, from 50 to 200 mg, is effective and well tolerated for the treatment of ED from 50 to 200 mg, and an increase in dosage is associated with a significant rise in effectiveness but not with more adverse events significantly.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 483.95
Formula C23H26ClN7O3
CAS Number 330784-47-9
Purity >99%
Solubility DMSO 80 mg/mL
Storage at -20°C
References

The effectiveness and safety of avanafil for erectile dysfunction: a systematic review and meta-analysis.
Wang H, et al. Curr Med Res Opin. 2014 Apr 14. PMID: 24701971.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Avanafil supplier, PDE, inhibitors

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